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Promoting Exogenous Repair in Multiple Sclerosis: Myelin Regeneration by Svetlana Bezukladova; Angela Genchi; Paola Panina-Bordignon; Gianvito Martino is a Medicine article available to read on EtoBox.

What is Promoting Exogenous Repair in Multiple Sclerosis: Myelin Regeneration about?

## Purpose of the review: Despite the significant progress in the development of disease-modifying treatments for multiple sclerosis (ms), repair of existing damage is still poorly addressed. current research focuses on stem cell-based therapies as a suitable alternative or complement to current drug therapies. ## Recent findings: Myelin damage is a hallmark of multiple sclerosis, and novel approaches leading to remyelination represent a promising tool to prevent neurodegeneration of the underlying axon. with increasing evidence of diminishing remyelination capacity of the ms brain with ageing and disease progression, exogenous cell transplantation is a promising therapeutic approach for restoration of oligodendrocyte precursor cell pool reserve and myelin regeneration. ## Summary: The present review summarizes recent developments of remyelinating therapies in multiple sclerosis, focusing on exogenous cell-based strategies and discussing related scientific, practical, and ethical concerns.

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Author

Svetlana Bezukladova; Angela Genchi; Paola Panina-Bordignon; Gianvito Martino

Published

2022

Language

EN

Field

Medicine (Health Sciences)