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Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2 by J. Milton; M.J. Slater; A.J. Bird; D. Spinks; G. Scott; C.E. Price; S. Downing; D.V.S. Green; S. Madar; R. Bethell; D.K. Stammers is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2 about?

A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with ICs0s in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.

Who reads Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2?

Author

J. Milton; M.J. Slater; A.J. Bird; D. Spinks; G. Scott; C.E. Price; S. Downing; D.V.S. Green; S. Madar; R. Bethell; D.K. Stammers

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)