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Modifications of the immune response induced by Histoplasma capsulatum products by Blanca H. Ruiz; Roger E. Carvajal; Librado Ortiz -Ortiz is a Medicine article available to read on EtoBox.

What is Modifications of the immune response induced by Histoplasma capsulatum products about?

To understand the host-parasite relationship in histoplasmosis, mice were inoculated with histoplasmin (HP), the filtrate of aged cultures of Histoplasrna capsulaturn, and the immune response of these mice towards sheep red blood cells (SRBC) and to trinitrophenyl hapten was studied. The filtrate abrogated completely the primary antibody response to both antigens as measured by the number of spleen hemolytic plaque forming cells when HP was administered at doses greater than 200 #g two days before the antigen. Suppression was elicited by HP when it was injected either intravenously, intraperitoneally, or subcutaneously. Inoculation with HP and antigen on the same day did not result in suppression. The secondary antibody response was not modified at any dose. Variation of the response with time was determined by counting the number of rosette forming cells (RFC) to SRBC every two days for a total of 21 days. Antibody-mediated RFC ('B' rosettes) were depressed throughout the experiment, while the number of non 'B', presumably T, RFC did not vary from control values. In animals inoculated with HP alone, high numbers of RFC were detected on day 11 after HP inoculation, suggesting that

Who reads Modifications of the immune response induced by Histoplasma capsulatum products?

Author

Blanca H. Ruiz; Roger E. Carvajal; Librado Ortiz -Ortiz

Publisher

Springer Netherlands; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0301-486X)

Published

1990

Language

EN

Field

Medicine (Health Sciences)