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Biomarkers in Heart Failure: From Research to Clinical Practice by Alexander E. Berezin; Alexander A. Berezin is a Medicine article available to read on EtoBox.

What is Biomarkers in Heart Failure: From Research to Clinical Practice about?

The aim of this narrative review is to summarize contemporary evidence on the use of circulating cardiac biomarkers of heart failure (HF) and to identify a promising biomarker model for clinical use in personalized point-of-care HF management. We discuss the reported biomarkers of HF classified into clusters, including myocardial stretch and biomechanical stress; cardiac myocyte injury; systemic, adipocyte tissue, and microvascular inflammation; cardiac fibrosis and matrix remodeling; neurohumoral activation and oxidative stress; impaired endothelial function and integrity; and renal and skeletal muscle dysfunction. We focus on the benefits and drawbacks of biomarker-guided assistance in daily clinical management of patients with HF. In addition, we provide clear information on the role of alternative biomarkers and future directions with the aim of improving the predictive ability and reproducibility of multiple biomarker models and advancing genomic, transcriptomic, proteomic, and metabolomic evaluations.

Who reads Biomarkers in Heart Failure: From Research to Clinical Practice?

Author

Alexander E. Berezin; Alexander A. Berezin

Publisher

Annals of Laboratory Medicine

Published

2022

Language

EN

Field

Medicine (Health Sciences)