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Can I read Demethylation of repetitive DNA sequences in neuroblastoma on EtoBox?
Demethylation of repetitive DNA sequences in neuroblastoma by Didier Thoraval; Jun-ichi Asakawa; Katharina Wimmer; Rork Kuick; Barbara Lamb; Bruce Richardson; Peter Ambros; Thomas Glover; Samir Hanash is a Medicine article available to read on EtoBox.
What is Demethylation of repetitive DNA sequences in neuroblastoma about?
Altered genomic methylcytosine content has been described for a number of tumor types, including neuroblastoma However, it remains to be determined for different tumor types whether specific loci or chromosomal regions are affected by a methylation change or whether the change is random. We have implemented a computer-based approach for the analysis of two-dimensional separations of human genomic restriction fragments. Through the use of methylation-sensitive restriction enzymes, methylation differences in genomic D N A between tumor and normal tissues can be detected. We report the cloning and sequencing of two fragments detectable in two-dimensional separations of genomic D N A of neuroblastomas. These fragments were found to be a part o f repetitive units that exhibited demethylation in neuroblastoma relative to other tumor types. Our finding of a distinct pattern of methylation of repetitive units in neuroblastoma suggests that altered methylation at certain loci may contribute to the biology of this tumor. Genes Chromosom Cancer /7: 234-244 (1996).
Who reads Demethylation of repetitive DNA sequences in neuroblastoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Didier Thoraval; Jun-ichi Asakawa; Katharina Wimmer; Rork Kuick; Barbara Lamb; Bruce Richardson; Peter Ambros; Thomas Glover; Samir Hanash
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Life Sciences)