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This study investigated the pharmacokinetic and pharmacodynamic interactions between 7.5 mg of zolpidem and 250 mg or 500 mg of caffeine in humans. The main findings were: 1) Caffeine increased the maximum plasma concentration and total exposure of zolpidem by 30-40% and decreased its oral clearance by up to 29% through inhibition of CYP1A2 metabolism. 2) Zolpidem increased sedation, impaired cognitive performance, slowed motor function, and impaired memory compared to placebo. 3) Caffeine partially bu

Author

Sls Nis

Language

EN