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Improved Water Solubility, Chemical Stability, Antioxidant and Anticancer Activity of Resveratrol via Nanoencapsulation with Pea Protein Nanofibrils by Jiang Yi; Qingyu He; Gaofei Peng; Yuting Fan is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Improved Water Solubility, Chemical Stability, Antioxidant and Anticancer Activity of Resveratrol via Nanoencapsulation with Pea Protein Nanofibrils about?

Fabricated pea protein isolate (PPI) nanofibrils were used as nanocarriers to encapsulate, stabilize and deliver resveratrol (RES). PPI nanofibrils possessed a dramatically higher surface hydrophobicity than PPI (native), and PPI nanofibrils exhibited nanoscale widths of 10 nm and average lengths of 1.0 μm. Fluorescence analyses demonstrated PPI nanofibrils had high binding constant with RES. Compared with RES (free), the aqueous solubility of RES was improved by approximately 1000-fold with PPI nanofibrils complex. DPPH and ABTS radical scavenging activity assays showed that the antioxidant capacity of RES was pronouncedly enhanced through the nanocomplexation with PPI nanofibrils. RES-PPI nanofibrils complexes exhibited higher antiproliferative activities than RES (free), with the cell viabilities of 52.6% and 38.5% for RES (free) and RES-PPI nanofibrils complex at 20 μg/mL. This study demonstrates that PPI nanofibrils can be utilized as novel nanocarriers for improvements of the water solubility, chemical stability and in vitro biological activities of hydrophobic nutraceuticals.

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Author

Jiang Yi; Qingyu He; Gaofei Peng; Yuting Fan

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)