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Initial Results of a Multi-center Trial Utilizing Xoft Axxent Electronic Brachytherapy to Deliver Intraoperative Radiation Therapy in the Treatment of Early-stage Breast Cancer by A. Dickler; O. Ivanov; M.C. Baird; D. Francescatti is a Medicine article available to read on EtoBox.

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2.5mm and an average statistical uncertainty of 2% were used in all calculations. A MATLAB program was developed in-house to compare the calculated dose profiles with the measurements obtained by an electron diode in a 3D water tank. The diode had no significant directional dependencies for geometries studied and its positioning uncertainty was less than 0.5mm. Analyses included the relative dose difference (RDD) in regions around maximum dose and distance-to-agreement (DTA) at larger depths and in beam penumbras. ## Results: The RDDs along the central beam axis were no greater than 3% at all depths within R90 for all energies, gantry angles and SSDs. The RDD increased with increasing depth but decreased with increasing energy. At R80, the RDDs were 3% and 8% for 16MeV and 9MeV beams, respectively, due to the inadequacy of dose grid size to account for rapid dose fall-off at 9MeV. However, the DTA was within one dose grid. The DTAs of the profiles in beam penumbra regions were within 3mm in most situations, and increased with increasing gantry angles and SSDs. Under an extreme condition at 40 gantry and 115cm SSD, the DTAs on the lateral side increased from 2mm to 5mm with depths f

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Author

A. Dickler; O. Ivanov; M.C. Baird; D. Francescatti

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)