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Lung Cancer Detection by Proton Transfer Reaction Mass-spectrometric Analysis of Human Breath Gas by Andreas Wehinger; Alex Schmid; Sergei Mechtcheriakov; Maximilian Ledochowski; Christoph Grabmer; Guenther A. Gastl; Anton Amann is a Chemistry article available to read on EtoBox.

What is Lung Cancer Detection by Proton Transfer Reaction Mass-spectrometric Analysis of Human Breath Gas about?

Background: Determination of the diagnostic usefulness of proton transfer reaction mass spectrometry (PTR-MS) for detecting primary lung cancer through analysis of volatile organic compounds (VOCs) in exhaled human breath was demonstrated in this investigation. Unlike, for example, gas-chromatographic analyses, PTR-MS can be used without time-consuming preconcentration of the gas samples. Methods: By means of PTR-MS, exhaled breath samples from primary lung cancer patients (n = 17) were analyzed and compared with both an overall control collective (controls total, n = 170) and three sub-collectives: hospital personnel (controls hospital, n = 35), age-matched persons (controls age, n = 25), and smokers (controls s, n = 60), respectively. Results: Among the VOCs present at reasonably high concentrations, the ones leading to the product ion at m/z = 31 (VOC-31, tentatively protonated formaldehyde) and m/z = 43 (VOC-43, tentatively a fragment of protonated iso-propanol), were found at significantly higher concentrations in the breath gas of the primary lung cancer patients as compared to the healthy controls at the following median concentrations (with interquartile distance, iqr): For

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Author

Andreas Wehinger; Alex Schmid; Sergei Mechtcheriakov; Maximilian Ledochowski; Christoph Grabmer; Guenther A. Gastl; Anton Amann

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1387-3806)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)