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The Activation of Amino Acids and Concepts of the Mechanism of Protein Synthesis by G. David Novelli; J. A. Demoss is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## FOUR FIGURES I n considering the enzymic mechanisms by which proteins are synthesized by living cells, problems are encountered that are unique to protein synthesis and have not been met with in considerations of the biosynthesis of other types of molecules. This is a consequence of proteins being constructed from a number of different amino acids, which are apparently arranged in a specific sequence, depending on the particular protein and the cell or species in which it is made. Furthermore, the specificity of proteins, whether considered as enzymes, hormones, or antigens, is maintained from generation to generation-making it clear that in some manner this specificity is under genetic control. Thus we have to consider, f o r the first time, enzymic mechanisms for the construction of specific molecules wherein the sequence of the building units, rather than being random as with glycogen and cholesterol, are under quite rigid control. One mechanism that can account f o r exact replication of specific protein molecules is the familiar template theory, first proposed by Breinl and Haurowitz in 1930 for antibody formation and generalized by Haurowitz in 1950 to include all protein

Who reads The Activation of Amino Acids and Concepts of the Mechanism of Protein Synthesis?

Author

G. David Novelli; J. A. Demoss

Publisher

Wiley (John Wiley & Sons); Wistar Institute of Anatomy and Biology; Wiley (ISSN 0095-9898)

Published

1957

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)