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Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study by Mahmoodpoor, Ata (author);Shadvar, Kamran (author);Sanaie, Sarvin (author);Hadipoor, Mir Reza (author);Pourmoghaddam, Mohammad Ata (author);Saghaleini, Seied Hadi (author) is a Medicine article available to read on EtoBox.

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## Background Critically ill patients frequently suffer from vitamin C deficiency. Previous studies showed that high doses of vitamin C administration had conflicting results on clinical outcomes in patients with severe sepsis, burns, and trauma. Because of the high incidence and morbidity/mortality with severe pneumonia, we aimed to investigate the effect of administration of high dose vitamin C in critically ill patients with severe pneumonia. ## Methods Eighty critically ill patients with pneumonia were enrolled in this randomized double-blinded clinical trial. Patients with a CURB-65 score > 3, one major criterion, or ≥ 3 minor criteria were considered as severe pneumonia. Patients were randomly assigned to intervention or placebo groups receiving standard treatment plus 60 mg/kg/day vitamin C as a continuous infusion or normal saline in the same volume correspondingly for 96 h. Serum levels of vitamin C were noted at baseline and 48 h after vitamin C administration. Duration of mechanical ventilation, ICU length of stay, PaO~2~/FiO~2~, and mortality rate were noted for all patients till the 28th day. Any complications related to the vitamin C administration were recorded. ## R

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Author

Mahmoodpoor, Ata (author);Shadvar, Kamran (author);Sanaie, Sarvin (author);Hadipoor, Mir Reza (author);Pourmoghaddam, Mohammad Ata (author);Saghaleini, Seied Hadi (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)