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- Folinic acid is a derivative of tetrahydrofolic acid that acts as a cofactor in DNA, RNA, and protein synthesis. It can limit the toxicity of drugs like methotrexate that inhibit folic acid by competing for the same transport processes into cells. - Folinic acid is rapidly converted to other tetrahydrofolic acid derivatives and distributed to tissues, being concentrated in the liver. It is excreted mainly through urine. - Folinic acid is used to diminish toxicity from high-dose methotrexate or overdoses

Author

Ellain Caballero

Language

EN