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Lack of Correlation Between External Fiducial Positions and Internal Tumor Positions During Breath-Hold CT by Sandeep Hunjan; George Starkschall; Karl Prado; Lei Dong; Peter Balter is a Medicine article available to read on EtoBox.

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## Purpose: For thoracic tumors, if four-dimensional computed tomography (4dct) is unavailable, the internal margin can be estimated by use of breath-hold (bh) ct scans acquired at end inspiration (ei) and end expiration (ee). by use of external surrogates for tumor position, bh accuracy is estimated by minimizing the difference between respiratory extrema bh and mean equivalent-phase free breathing (fb) positions. we tested the assumption that an external surrogate for bh accuracy correlates with internal tumor positional accuracy during bh ct. ## Methods and materials: In 16 lung cancer patients, 4dct images, as well as bh ct images at ei and ee, were acquired. absolute differences between bh and mean equivalent-phase (fb) positions were calculated for both external fiducials and gross tumor volume (gtv) centroids as metrics of external and internal bh accuracy, respectively, and the results were correlated. ## Results: At ei, the absolute difference between mean fb and bh fiducial displacement correlated poorly with the absolute difference between fb and bh gtv centroid positions on ct images (r(2) = 0.11). similarly, at ee, the absolute difference between mean fb and bh fiducia

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Author

Sandeep Hunjan; George Starkschall; Karl Prado; Lei Dong; Peter Balter

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)