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Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by Rearrangement from Indoline‐2‐methanol to 2,2,3‐Trisubstituted Tetrahydroquinoline: Application to an Efficient Total Synthesis of Natural Virantmycin by Mayuko Ori; Narihiro Toda; Kazuko Takami; Keiko Tago; Hiroshi Kogen is a Chemistry article available to read on EtoBox.

What is Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by Rearrangement from Indoline‐2‐methanol to 2,2,3‐Trisubstituted Tetrahydroquinoline: Application to an Efficient Total Synthesis of Natural Virantmycin about?

The stereoselective construction of chiral quaternary stereocenters is one of the most challenging problems in synthetic organic chemistry. [1] Substituted tetrahydroquinolines and tetrahydroisoquinolines have attracted considerable attention from organic and medicinal chemists, primarily because they display a wide range of physiological activities. [1c, 2] These ring systems are present in various important natural products. [2] Moreover, chiral quaternary centers are often essential for these compounds. For example, chiral contiguous quaternary and tertiary stereocenters are found in virantmycin (6 a), [3] a potent antiviral agent (Scheme 1). Recently, Shibasaki et al. reported an elegant synthesis of 1,1-disubstituted tetrahy-

Who reads Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by Rearrangement from Indoline‐2‐methanol to 2,2,3‐Trisubstituted Tetrahydroquinoline: Application to an Efficient Total Synthesis of Natural Virantmycin?

Author

Mayuko Ori; Narihiro Toda; Kazuko Takami; Keiko Tago; Hiroshi Kogen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 0044-8249)

Published

2003

Language

EN

Field

Chemistry (Physical Sciences)