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Anthelmintic Nitazoxanide Protects Against Experimental Pulmonary Fibrosis by Xu‐Yang Chen; Yan‐Chao Dong; Yuan‐Yuan Yu; Man Jiang; Wen‐Jie Bu; Ping Li; Zhi‐Jie Sun; De‐Li Dong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Anthelmintic Nitazoxanide Protects Against Experimental Pulmonary Fibrosis about?

## Abstract ## Background and Purpose Nitazoxanide is a therapeutic anthelmintic drug. Our previous studies found that nitazoxanide and its metabolite tizoxanide activated adenosine 5′‐monophosphate‐activated protein kinase (AMPK) and inhibited signal transducer and activator of transcription 3 (STAT3) signals. As AMPK activation and/or STAT3 inhibition are targets for treating pulmonary fibrosis, we hypothesized that nitazoxanide would be effective in experimental pulmonary fibrosis. ## Experimental Approach The mitochondrial oxygen consumption rate of cells was measured by using the high‐resolution respirometry system Oxygraph‐2K. The mitochondrial membrane potential of cells was evaluated by tetramethyl rhodamine methyl ester (TMRM) staining. The target protein levels were measured by using western blotting. The mice pulmonary fibrosis model was established through intratracheal instillation of bleomycin. The examination of the lung tissues changes were carried out using haematoxylin and eosin (H&E), and Masson staining. ## Key Results Nitazoxanide and tizoxanide activated AMPK and inhibited STAT3 signalling in human lung fibroblast cells (MRC‐5 cells). Nitazoxanide and tizoxani

Who reads Anthelmintic Nitazoxanide Protects Against Experimental Pulmonary Fibrosis?

Author

Xu‐Yang Chen; Yan‐Chao Dong; Yuan‐Yuan Yu; Man Jiang; Wen‐Jie Bu; Ping Li; Zhi‐Jie Sun; De‐Li Dong

Publisher

Wiley

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)