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The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression by Alexander L. W. Smith; Catherine J. Harmer; Philip J. Cowen; Susannah E. Murphy is a Medicine article available to read on EtoBox.

What is The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression about?

Clinical depression is a common, debilitating and heterogenous disorder. Existing treatments for depression are inadequate for a significant minority of patients and new approaches are urgently needed. A wealth of evidence implicates the serotonin 1A (5-HT 1A ) receptor in the pathophysiology of depression. Stimulation of the 5-HT 1A receptor is an existing therapeutic target for treating depression and anxiety, using drugs such as buspirone and tandospirone. However, activation of 5-HT 1A raphe autoreceptors has also been suggested to be responsible for the delay in the therapeutic action of conventional antidepressants such as selective serotonin reuptake inhibitors (SSRIs). This narrative review provides a brief overview of the 5-HT 1A receptor, the evidence implicating it in depression and in the effects of conventional antidepressant treatment. We highlight that pre-and post-synaptic 5-HT 1A receptors may have divergent roles in the pathophysiology and treatment of depression. To date, developing this understanding to progress therapeutic discovery has been limited, partly due to a paucity of specific pharmacological probes suitable for use in humans. The development of 5-HT 1

Who reads The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression?

Author

Alexander L. W. Smith; Catherine J. Harmer; Philip J. Cowen; Susannah E. Murphy

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)