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The regulation of bcr-abl in hypoxia is through the mTOR pathway by Clapper, Erin; Di Trapani, Giovanna; Tonissen, Kathryn F. is a Medicine article available to read on EtoBox.

What is The regulation of bcr-abl in hypoxia is through the mTOR pathway about?

Chronic myeloid leukemia (CML) is usually characterized by the formation of the fusion onco-protein bcr-abl. Therefore, the majority of CML treatments are bcr-abl specific tyrosine kinase inhibitors (TKIs). TKI resistance in CML treatment is becoming a major obstacle in managing this disease. One well-studied form of drug resistance is hypoxia-induced drug resistance, a phenomenon observed in many other cancers. This study aimed to determine the efficacy of TKIs in CML cells cultured in hypoxia. It was observed that bcr-abl translation was severely halted in hypoxia, rendering TKIs ineffective. We found that the mechanism by which bcr-abl protein levels were being suppressed in hypoxia was through the mTOR pathway, specifically via ribosomal protein S6 (RPS6). This information is vital to the improvement of CML treatments, as it can be used to determine how to best combat hypoxia-induced drug resistance in CML and subsequently to identify new targets for treatment.

Who reads The regulation of bcr-abl in hypoxia is through the mTOR pathway?

Author

Clapper, Erin; Di Trapani, Giovanna; Tonissen, Kathryn F.

Publisher

Informa plc; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 1042-8194)

Published

2020

Language

EN

Field

Medicine (Health Sciences)