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What is Improved N-Hydroxysuccinimide Synthesis about?

N-Hydroxysuccinimide is an intermediate used in peptide chemistry to prepare various activated esters of acylamino acids (4,5,6,7). The compound has been known for many years (8,9,l0), but has only recently been obtained in moderate amounts by fusion of succinic anhydride either with hydroxylamine (11) o r hydroxylamine hydrochloride, followed by fractional crystallization. A simple alternative to this later procedure exists in the addition of succinic anhydride to a solution of hydroxylamine, then hea

Author

moutaz shaldum

Language

EN