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Metabolic flux analysis of Shewanella spp. reveals evolutionary robustness in central carbon metabolism by Yinjie J. Tang; Hector Garcia Martin; Paramvir S. Dehal; Adam Deutschbauer; Xavier Llora; Adam Meadows; Adam Arkin; Jay. D. Keasling is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract __Shewanella__ spp. are a group of facultative anaerobic bacteria widely distributed in marine and freshwater environments. In this study, we profiled the central metabolic fluxes of eight recently sequenced __Shewanella__ species grown under the same condition in minimal medium with [3‐^13^C] lactate. Although the tested __Shewanella__ species had slightly different growth rates (0.23–0.29 h^−1^) and produced different amounts of acetate and pyruvate during early exponential growth (pseudo‐steady state), the relative intracellular metabolic flux distributions were remarkably similar. This result indicates that __Shewanella__ species share similar regulation in regard to central carbon metabolic fluxes under steady growth conditions: the maintenance of metabolic robustness is not only evident in a single species under genetic perturbations (Fischer and Sauer, 2005; Nat Genet 37(6):636–640), but also observed through evolutionary related microbial species. This remarkable conservation of relative flux profiles through phylogenetic differences prompts us to introduce the concept of metabotype as an alternative scheme to classify microbial fluxomics. On the other hand, __S
Who reads Metabolic flux analysis of Shewanella spp. reveals evolutionary robustness in central carbon metabolism?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yinjie J. Tang; Hector Garcia Martin; Paramvir S. Dehal; Adam Deutschbauer; Xavier Llora; Adam Meadows; Adam Arkin; Jay. D. Keasling
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)