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A Prospective Study of Squamous Head and Neck Carcinoma Immunologic Aberrations in Patients Who Develop Recurrent Disease by Andrew T. Huang; Nelda G. Mold; Samuel R. Fisher; B. Alton Brantley; T. Boyce Cole; Mary Jane Wallman; Ian R. Crocker is a Medicine article available to read on EtoBox.
What is A Prospective Study of Squamous Head and Neck Carcinoma Immunologic Aberrations in Patients Who Develop Recurrent Disease about?
In a prospective study of squamous head and neck cancer, the pretreatment peripheral blood of 125 patients was examined for lymphocyte subclass and in vitro immunologic function. After 4 years of followup, 49 recurrences of disease were observed. Lymphocytes from patients with recurrent disease showed elevated interleukin-2 (IL-2) production and a tendency towards increased response to mitogens in comparison to those without recurrence. When disease-free survival is analyzed on the basis of IL-2 levels, patients with high relative IL-2 synthesis (21) had a 40% poorer prognosis than patients with low relative IL-2 levels (4). The difference is significant at a P value of 0.02. Since IL-2 synthesis occurs with antigenic stimulation, it is postulated that patients who have a high IL-2 synthesis in their pretreatment lymphocytes may have had prior stimulation by circulating tumor antigen. Such immune response by the host may be successful in destroying the antigenic tumor cells but may leave the undifferentiated, less antigenic tumor cells to grow and metastasize. Thus, elevated IL-2 synthesis in pretreatment lymphocytes predicts a poorer prognosis. Cancer 5 9 1721 -1 726, 1987. QUAMOU
Who reads A Prospective Study of Squamous Head and Neck Carcinoma Immunologic Aberrations in Patients Who Develop Recurrent Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Andrew T. Huang; Nelda G. Mold; Samuel R. Fisher; B. Alton Brantley; T. Boyce Cole; Mary Jane Wallman; Ian R. Crocker
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1987
- Language
- EN
- Field
- Medicine (Health Sciences)