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Lysosomal and Alkaline Phosphatase Activity Indicate Macromolecule Transport Across the Uterine Epithelium in Two Viviparous Skinks with Complex Placenta by Joanna M. Biazik; Michael B. Thompson; Christopher R. Murphy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Lysosomal and Alkaline Phosphatase Activity Indicate Macromolecule Transport Across the Uterine Epithelium in Two Viviparous Skinks with Complex Placenta about?

## Abstract In addition to water and small inorganic ions, macromolecules traverse the uterine epithelium in viviparous skinks to be absorbed by the developing fetus. In some species of lizards with complex placenta, the paracellular pathway across the uterine epithelium becomes tighter and more highly regulated as gestation progresses, suggesting that the transcellular pathway may be an alternative route for molecules to travel across the epithelium. In this study, we identified an extensive formation of a lysosomal system in the apical region of uterine epithelial cells in the highly secretory omphaloplacental region of the skink placenta in two species from the __Pseudemoia__ genus. We suggest that this lysosomal system assists apocrine secretion by digesting large macromolecules into smaller particles, allowing more effective transport across the plasma membrane of uterine epithelial cells. We also demonstrate alkaline phosphatase (AP) activity along the apical plasma membrane of uterine epithelial cells in the omphaloplacental region of skink uterus, an enzyme usually associated with active transport in secretory cells. Apocrine secretion, an extensive lysosomal system and AP

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Author

Joanna M. Biazik; Michael B. Thompson; Christopher R. Murphy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1552-5007)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)