Opening book details…
Can I read Gene Therapy of Genetic Diseases and Cancer on EtoBox?
Gene Therapy of Genetic Diseases and Cancer by R. Scott McIvor is a Medicine article available to read on EtoBox.
What is Gene Therapy of Genetic Diseases and Cancer about?
Abstract: The scope of gene transfer applications in human therapy has expanded enormously over the last 15 years to include not only several types of genetic diseases but also a variety of genetic approaches to the treatment of cancer. Hematopoietic stem cells have been considered excellent targets for therapeutic gene transfer because of their capacity for self‐renewal and for differentiation into multiple cellular lineages. Retrovirus‐mediated gene transfer has been tested for treatment of diseases that specifically affect the hematopoietic system, such as adenosine deaminase deficiency and chronic granulomatous disease. Storage disorders such as Gaucher disease, Hurler syndrome and Hunter syndrome, genetic deficiencies that affect a broad range of tissue types, may also be amenable to treatment by gene transfer into hematopoietic cells, owing to the release of enzyme expressed in transduced cells with subsequent uptake by untransduced cells (“metabolic cross‐correction”). Hematopoietic stem cells may also be targeted for introduction of drug‐resistance genes for the purpose of protecting normal tissues from the toxic side‐effects of cancer chemotherapeutic agents, thus allowing
Who reads Gene Therapy of Genetic Diseases and Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- R. Scott McIvor
- Publisher
- Wiley
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)