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Small Molecule Conformational Analysis by aisymumtaza is a document available to read on EtoBox.
This article analyzes small molecule conformational preferences using data from the Cambridge Structural Database (CSD) and the Protein Data Bank (PDB), focusing on drug-like molecules. It discusses the relevance of torsion angle distributions for medicinal chemistry and compares conformations of organic fragments in both databases. The findings highlight the importance of using crystallographic data for drug design and the correlation between observed conformations and those of protein-bound ligands.
- Author
- aisymumtaza
- Language
- EN