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Metabolism at the Crossroads of Inflammation and Fibrosis in Chronic Kidney Disease by Verónica Miguel & Isaac W. Shaw & Rafael Kramann is a book available to read on EtoBox.

What is Metabolism at the Crossroads of Inflammation and Fibrosis in Chronic Kidney Disease about?

Nature Reviews Nephrology, doi:10.1038/s41581-024-00889-zChronic kidney disease (CKD), defned as persistent (>3 months) Introductionkidney functional loss, has a growing prevalence (>10% worldwide Kidney metabolism in population) and limited treatment options. Fibrosis driven by the homeostasisaberrant accumulation of extracellular matrix is the fnal common Metabolic alterations of nonpathway of nearly all types of chronic repetitive injury in the kidney and immune kidney cells in CKDis considered a hallmark of CKD. Myofbroblasts are key extracellular Metabolic characteristics of kidney immune cells in CKDmatrix-producing cells that are activated by crosstalk between damaged Future perspectives on tubules and immune cells. Emerging evidence indicates that metabolic metabolism-directed alterations are crucial contributors to the pathogenesis of kidney therapies against CKDfbrosis by afecting cellular bioenergetics and metabolite signalling. ConclusionsImmune cell functions are intricately connected to their metabolic characteristics, and kidney cells seem to undergo cell-type-specifc metabolic shifts in response to damage, all of which can determine injury and repair responses in C

Author

Verónica Miguel & Isaac W. Shaw & Rafael Kramann

Publisher

x

Published

2024

Language

EN