Opening book details…
Can I read ctDNA to Guide Treatment of Colorectal Cancer: Ready for Standard of Care? on EtoBox?
ctDNA to Guide Treatment of Colorectal Cancer: Ready for Standard of Care? by Alberto Puccini; Valentino Martelli; Alessandro Pastorino; Stefania Sciallero; Alberto Sobrero is a Medicine article available to read on EtoBox.
What is ctDNA to Guide Treatment of Colorectal Cancer: Ready for Standard of Care? about?
Circulating tumor DNA (ctDNA) has already shown clinically relevant results in early-stage colon cancer patient management. Its prognostic value is by far much stronger than that of the available clinico-pathological biomarkers, therefore, has the potential to personalize the treatment after radical surgery through intensifying or de-intensifying the adjuvant therapy. Further developments and improvements should be pursued by (a) optimizing ctDNA assays and (b) validating its clinical utility in the different stages of this disease. Two main avenues of ctDNA testing are being pursued: tumor-informed vs tumor-agnostic assays. Two main clinical trial designs are under study: ctDNA-based strategy and ctDNA-by-treatment interaction. The former needs large sample sizes to address the main questions of the studies; thus, the target delta benefit may be the main challenge in these trial designs. The latter may be challenged by unavoidable contamination bias. To date, several clinical trials are ongoing worldwide. We believe that this large number of trials may provide an excellent common database for the demonstration of surrogacy of ctDNA for the classical 3-year disease-free survival en
Who reads ctDNA to Guide Treatment of Colorectal Cancer: Ready for Standard of Care??
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alberto Puccini; Valentino Martelli; Alessandro Pastorino; Stefania Sciallero; Alberto Sobrero
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)