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Parvovirus B19 infection in Taiwanese patients with hematological disorders by Yuan‐Ming Lee; Wen‐Hui Tsai; Jie‐Yu You; Benjamin Ing‐Tiau Kuo; Pen‐Tung Liao; Chi‐Kuan Ho; Hui‐Chi Hsu is a Medicine article available to read on EtoBox.

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## Abstract Human parvovirus B19 has a strong tissue tropism for erythroid progenitor cells and is a causative agent for anemia. However, it remains unclear whether patients with hematological disorders are at a higher risk of B19 infection. In the present study, we evaluated the prevalence of B19 infection in 278 patients with hematological disorders by indirect antibody capture enzyme‐linked immunosorbent assay. Virus inoculation into cell culture (of TF‐6, WRL‐68, and HL‐60) was carried out using serum from patients with positive IgM anti‐B19 and was then examined by nested polymerase chain reaction, dot‐blot analysis, and sequence analysis. Our data demonstrated that the total seropositive rates of either IgG or IgM were 71.9%. The seropositive rates increase significantly with age (__P__ < 0.001). After adjustment for age, the seropositive rate was significantly higher in our patients than in the general population with standardized rate ratio of 1.56 (95% CI = 1.43–1.68). No significant difference was found among different disease subgroups (__P__ = 0.311). Nine patients (3.2%) had active B19 infection with positive IgM antibody, with four diagnosed as having idiopathic throm

Who reads Parvovirus B19 infection in Taiwanese patients with hematological disorders?

Author

Yuan‐Ming Lee; Wen‐Hui Tsai; Jie‐Yu You; Benjamin Ing‐Tiau Kuo; Pen‐Tung Liao; Chi‐Kuan Ho; Hui‐Chi Hsu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2003

Language

EN

Field

Medicine (Health Sciences)