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Interaction of Organometallic Cationic Complex Ions Containing Terpyridine Ligands with Nucleic Acids: an Investigation on Aggregative Phenomena by Marco Casamento; Giuseppe Enrico Arena; Carla Lo Passo; Ida Pernice; Andrea Romeo; Luigi Monsù Scolaro is a Chemistry article available to read on EtoBox.

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nteraction of metal complexes with DNA is a topic interest and many efforts have been devoted to the factors that determine aMinity and al interaction mode for ie aeids is intercalation rman [3] in explaining the nucleic acidsofseveral dyes, such rties can be finely tuned throu metal and of the ancillary lig, wide application in this area as good probes of electronic and steric effects on the binding process [ 1.2 1. Studieson intenzalation with DNA oforganometalliccompounds are rare [S,lO]. Recently, taking advantage of the presence in the literature of a clear and detailed characterization of the interactions of the complex 2-hydroxyethanethiolato-(2,2',2"-terpyridine)platinum( II) [ IW terpy 1 (HET) I\* with DNA [ I I-221, WC carried nut an investigation on the closely related organsmetallic complex I Pt( terpy 1 Me 1 ' ion [ IQ]. The most interesting feature of this s irs is its marked tendency to self-aggregate, greater than that of the corresponding [ Pt( terpy) (WET) ] '. As a consequence, on interacting with a double stranded DNA, a preliminary reversible distribution of aggregates an the surface of the nucleic acid is evidenced, followed by a proper intercatstive process.

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Author

Marco Casamento; Giuseppe Enrico Arena; Carla Lo Passo; Ida Pernice; Andrea Romeo; Luigi Monsù Scolaro

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0020-1693)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)