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Can I read Salmonella Typhimurium Discreet-invasion of the Murine Gut Absorptive Epithelium on EtoBox?
Salmonella Typhimurium Discreet-invasion of the Murine Gut Absorptive Epithelium by Stefan A. Fattinger; Desirée Böck; Maria Letizia Di Martino; Sabrina Deuring; Pilar Samperio Ventayol; Viktor Ek; Markus Furter; Saskia Kreibich; Francesco Bosia; Anna A. Müller-Hauser; Bidong D. Nguyen; Manfred Rohde; Martin Pilhofer; Wolf-Dietrich Hardt; Mikael E. Sellin is a Medicine article available to read on EtoBox.
What is Salmonella Typhimurium Discreet-invasion of the Murine Gut Absorptive Epithelium about?
__Salmonella enterica__ serovar Typhimurium (__S__.Tm) infections of cultured cell lines have given rise to the ruffle model for epithelial cell invasion. According to this model, the Type-Three-Secretion-System-1 (TTSS-1) effectors SopB, SopE and SopE2 drive an explosive actin nucleation cascade, resulting in large lamellipodia- and filopodia-containing ruffles and cooperative __S__.Tm uptake. However, cell line experiments poorly recapitulate many of the cell and tissue features encountered in the host’s gut mucosa. Here, we employed bacterial genetics and multiple imaging modalities to compare __S__.Tm invasion of cultured epithelial cell lines and the gut absorptive epithelium __in vivo__ in mice. In contrast to the prevailing ruffle-model, we find that absorptive epithelial cell entry in the mouse gut occurs through “discreet-invasion”. This distinct entry mode requires the conserved TTSS-1 effector SipA, involves modest elongation of local microvilli in the absence of expansive ruffles, and does not favor cooperative invasion. Discreet-invasion preferentially targets apicolateral hot spots at cell–cell junctions and shows strong dependence on local cell neighborhood. This pro
Who reads Salmonella Typhimurium Discreet-invasion of the Murine Gut Absorptive Epithelium?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Stefan A. Fattinger; Desirée Böck; Maria Letizia Di Martino; Sabrina Deuring; Pilar Samperio Ventayol; Viktor Ek; Markus Furter; Saskia Kreibich; Francesco Bosia; Anna A. Müller-Hauser; Bidong D. Nguyen; Manfred Rohde; Martin Pilhofer; Wolf-Dietrich Hardt; Mikael E. Sellin
- Publisher
- Public Library of Science; San Francisco CA: Public Library of Science, [2005]-; Public Library of Science (PLoS) (ISSN 1553-7366)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)