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Assessment of a Computerized Quantitative Quality Control Tool for Whole Slide Images of Kidney Biopsies by Yijiang Chen; Jarcy Zee; Abigail Smith; Catherine Jayapandian; Jeffrey Hodgin; David Howell; Matthew Palmer; David Thomas; Clarissa Cassol; Alton B Farris; Kathryn Perkinson; Anant Madabhushi; Laura Barisoni; Andrew Janowczyk is a Medicine article available to read on EtoBox.
What is Assessment of a Computerized Quantitative Quality Control Tool for Whole Slide Images of Kidney Biopsies about?
Inconsistencies in the preparation of histology slides and whole-slide images (WSIs) may lead to challenges with subsequent image analysis and machine learning approaches for interrogating the WSI. These variabilities are especially pronounced in multicenter cohorts, where batch effects (i.e. systematic technical artifacts unrelated to biological variability) may introduce biases to machine learning algorithms. To date, manual quality control (QC) has been the de facto standard for dataset curation, but remains highly subjective and is too laborious in light of the increasing scale of tissue slide digitization efforts. This study aimed to evaluate a computer-aided QC pipeline for facilitating a reproducible QC process of WSI datasets. An open source tool, HistoQC, was employed to identify image artifacts and compute quantitative metrics describing visual attributes of WSIs to the Nephrotic Syndrome Study Network (NEPTUNE) digital pathology repository. A comparison in inter-reader concordance between HistoQC aided and unaided curation was performed to quantify improvements in curation reproducibility. HistoQC metrics were additionally employed to quantify the presence of batch effec
Who reads Assessment of a Computerized Quantitative Quality Control Tool for Whole Slide Images of Kidney Biopsies?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yijiang Chen; Jarcy Zee; Abigail Smith; Catherine Jayapandian; Jeffrey Hodgin; David Howell; Matthew Palmer; David Thomas; Clarissa Cassol; Alton B Farris; Kathryn Perkinson; Anant Madabhushi; Laura Barisoni; Andrew Janowczyk
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)