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Deciphering the Structural Enigma of HLA Class-II Binding Peptides for Enhanced Immunoinformatics-based Prediction of Vaccine Epitopes by Chatterjee, Deepyan; Priyadarshini, Pragya; Das, Deepjyoti K.; Mushtaq, Khurram; Singh, Balvinder; Agrewala, Javed N. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Deciphering the Structural Enigma of HLA Class-II Binding Peptides for Enhanced Immunoinformatics-based Prediction of Vaccine Epitopes about?

Vaccines remain the most efficacious means to avoid and eliminate morbid diseases associated with high morbidity and mortality. Clinical trials indicate the gaining impetus of peptide vaccines against diseases for which an effective treatment still remains obscure. CD4 T-cell-based peptide vaccines involve immunization with antigenic determinants from pathogens or neoplastic cells that possess the ability to elicit a robust T helper cell response, which subsequently activates other arms of the immune system. The available predictors of human leukocyte antigen II (HLA-II) binding peptides are sequence-based techniques, which ostensibly have balanced sensitivity and specificity. Structural analysis and understanding of the cognate peptide and HLA-II interactions are essential to empirically derive a successful peptide vaccine. However, the availability of structure-based epitope prediction algorithms is inadequate compared with sequence-based prediction methods. The present study is an attempt to understand the structural aspects of HLA-II binders by analyzing the Protein Data Bank (PDB) complexes of pHLA-II. Furthermore, we mimic the peptide exchange mechanism and demonstrate the st

Who reads Deciphering the Structural Enigma of HLA Class-II Binding Peptides for Enhanced Immunoinformatics-based Prediction of Vaccine Epitopes?

Author

Chatterjee, Deepyan; Priyadarshini, Pragya; Das, Deepjyoti K.; Mushtaq, Khurram; Singh, Balvinder; Agrewala, Javed N.

Publisher

American Chemical Society; American Chemical Society (ACS) (ISSN 1535-3893)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)