Can I read AB0832 IDENTIFICATION OF NATIVE AND CITRULLINATED AUTOANTIBODIES TO PSORIASIS RELATED-ANTIGEN PsoP27 IN SYNOVIAL FLUIDS OF PATIENTS WITH PSORIATIC ARTHRITIS on EtoBox?

AB0832 IDENTIFICATION OF NATIVE AND CITRULLINATED AUTOANTIBODIES TO PSORIASIS RELATED-ANTIGEN PsoP27 IN SYNOVIAL FLUIDS OF PATIENTS WITH PSORIATIC ARTHRITIS by M. Slobodkin; S. Gertel; A. Polachek; V. Furer; O. Elkayam is a Medicine article available to read on EtoBox.

What is AB0832 IDENTIFICATION OF NATIVE AND CITRULLINATED AUTOANTIBODIES TO PSORIASIS RELATED-ANTIGEN PsoP27 IN SYNOVIAL FLUIDS OF PATIENTS WITH PSORIATIC ARTHRITIS about?

Background: Psoriatic arthritis (PsA) is an inflammatory joint disease. Unlike rheumatoid arthritis (RA), PsA is a “seronegative disease”, with no diagnostic biomarkers, hence diagnosis is based on clinical evaluation alone. PsA is closely associated with psoriasis (PsO), with up to 1/3 of psoriatic patients developing PsA via unknown mechanism. PsoP27 is an antigen present in mast cells in psoriatic lesions and absent in skin uninvolved by psoriasis or in healthy controls (1), thus playing a significant role in inflammatory reaction in the psoriatic skin lesion (2). Its levels in skin lesions correlate with psoriasis activity (3). Though speculated to be involved in other inflammatory processes, this antigen has not been investigated in relation to PsA. Objectives: Our aim was to identify and determine the level of native and citrullinated PsoP27 antibodies (Ab) in serum and synovial fluid of patients with PsA compared to RA and osteoarthritis (OA), exploring a potential common inflammatory pathway in PsA and PsO. Methods: Synovial fluid (SF) and serum of PsA (n=35, m:f 24:11, median age 48, PsA median duration 8Y, PsO median duration 15Y) and RA (n=11, m:f 2:9, median age 60, med

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Author

M. Slobodkin; S. Gertel; A. Polachek; V. Furer; O. Elkayam

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)