Opening book details…
Can I read Methyllycaconitine Analogues Have Mixed Antagonist Effects at Nicotinic Acetylcholine Receptors on EtoBox?
Methyllycaconitine Analogues Have Mixed Antagonist Effects at Nicotinic Acetylcholine Receptors by David Barker; Diana H.-S. Lin; Jane E. Carland; Cindy P.-Y. Chu; Mary Chebib; Margaret A. Brimble; G. Paul Savage; Malcolm D. McLeod is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Methyllycaconitine Analogues Have Mixed Antagonist Effects at Nicotinic Acetylcholine Receptors about?
Bicyclic analogues of methyllycaconitine (MLA), such as 12, have been synthesised that incorporate the C1-OMe substituent present in the natural product. Electrophysiology experiments using Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) were conducted on these analogues and a related tricyclic analogue 2. The most potent compound, 2, was an antagonist at all receptors studied but displayed different antagonist effects at each receptor subtype. This study more clearly defines the biological effects of MLA analogues at nAChRs and demonstrates that these analogues are not selective ligands for the a7 nAChR subtype.
Who reads Methyllycaconitine Analogues Have Mixed Antagonist Effects at Nicotinic Acetylcholine Receptors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- David Barker; Diana H.-S. Lin; Jane E. Carland; Cindy P.-Y. Chu; Mary Chebib; Margaret A. Brimble; G. Paul Savage; Malcolm D. McLeod
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)