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Can I read Concise synthesis and biological activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3 on EtoBox?
Concise synthesis and biological activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3 by Shinobu Honzawa; Yoshitomo Suhara; Ken-ichi Nihei; Nozomi Saito; Seishi Kishimoto; Toshie Fujishima; Masaaki Kurihara; Takayuki Sugiura; Keizo Waku; Hiroaki Takayama; Atsushi Kittaka is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Concise synthesis and biological activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3 about?
We found a concise route to the Trost A-ring precursor enyne for synthesizing 2a-alkylated 1a,25-dihydroxyvitamin D 3 (1) from d-glucose. The enynes were coupled with the 20-epi-CD ring part to study the effect of the double modification of 2asubstitution and 20-epimerization upon biological activities of 1. The novel three analogues of 2a-alkyl-and four analogues of 2a-(o-hydroxyalkyl)-20-epi-1a,25-dihydroxyvitamin D 3 (5b-d and 6a-d) showed higher binding affinity for vitamin D receptor (VDR) and more potent activity in induction of HL-60 cell differentiation than those of the natural hormone 1.
Who reads Concise synthesis and biological activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shinobu Honzawa; Yoshitomo Suhara; Ken-ichi Nihei; Nozomi Saito; Seishi Kishimoto; Toshie Fujishima; Masaaki Kurihara; Takayuki Sugiura; Keizo Waku; Hiroaki Takayama; Atsushi Kittaka
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)