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Prognostic implications of T stage in different pathological types of colorectal cancer: an observational study using SEER population-based data by Yao, Nan (author);Li, Wenqiang (author);Wang, Jiwei (author);Chu, Hongyuan (author);Duan, Ning (author);Niu, Xinyu (author);Yu, Guoyong (author);Qu, Jun (author) is a Medicine article available to read on EtoBox.

What is Prognostic implications of T stage in different pathological types of colorectal cancer: an observational study using SEER population-based data about?

## Objectives Colorectal cancer (CRC) encompasses a spectrum of pathological types, each exhibiting distinct biological behaviours that challenge the conventional T-staging system’s predictive efficiency. Thus, this study aims to explore the prognostic significance of the T stage across various CRC pathological types, seeking to unravel insights that could enhance prognostic assessment in this complex disease. ## Study design We performed a retrospective analysis using the Surveillance, Epidemiology, and End Results (SEER) database for primary CRC cases from 2010 to 2017. ## Setting The SEER database, comprising data from various US regional and state cancer registries, identified 39 321 patients with CRC. Our analysis focused on the three most common CRC pathological types: adenocarcinoma (AC), mucinous adenocarcinoma (MC) and signet ring cell carcinoma (SR). ## Primary outcome measures The study used Cox regression models to evaluate how different pathological characteristics impact mortality risk in patients with CRC. Time-dependent receiver operating characteristic curves were also applied to assess the prognostic accuracy of various tumour node metastasis (TNM)/non-mucinous (N

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Author

Yao, Nan (author);Li, Wenqiang (author);Wang, Jiwei (author);Chu, Hongyuan (author);Duan, Ning (author);Niu, Xinyu (author);Yu, Guoyong (author);Qu, Jun (author)

Publisher

BMJ Publishing Group

Published

2024

Language

EN

Field

Medicine (Health Sciences)