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revealed hemoglobin of 13.2 g% and platelets 183 O00/mm 3. The WBC varied from an initial 22 O00/mm 3 of which 52% were mature eosinophils to 93 O00/mm 3 with 72% mature eosinophils. The bone marrow was hypercellular with 50% eosinophils or eosinophil precursors and gradually evolved into a leukemic picture with increased numbers of myeloblasts and megakaryocytic and erythroid hypoplasia. His drug treatment included hydroxyurea, vincristine and 6-mercaptopurine. He died 18 months after the initial presentation from intractable cardiac failure. The salient findings at autopsy included cardiomegaly, subendocardial fibrosis and mural thrombosis. Microscopy revealed predominantly mature eosinophilic infiltrates In the myocardlum, brain, liver and spleen. The clinical and pathologic findings in this case are in keeping with eosinophilic leukemia. We suggest certain criteria that can help in separating eosinophillc leukemia from idiopathic hypereosinophilic syndrome.

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Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

1984

Language

EN

Field

Medicine (Health Sciences)