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The study investigates the role of interleukin 33 (IL-33) in stimulating interleukin 6 (IL-6) expression in MLO-Y4 osteocyte-like cells. Results show that IL-33 enhances IL-6 expression through the activation of NF-κB, JNK/AP-1, and p38 MAPK signaling pathways, with the involvement of the IL-33 receptor ST2L. These findings suggest that IL-33 plays a significant role in regulating osteocyte function and bone remodeling processes.
- Author
- Luis Seixas
- Language
- EN