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Rapid, simultaneous determination of headspace oxygen and moisture in pharmaceutical packages using μGC by Hui Xu; Allen C. Templeton; Marta Zwierzynski; Rajiv Mahajan; Robert A. Reed is a Chemistry article available to read on EtoBox.

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The rapid, accurate determination of headspace oxygen and moisture in various pharmaceutical packages is important for both product packaging development and the implementation of new packaging technologies. Current headspace oxygen measurement techniques suffer from serious drawbacks in terms of potential sampling contamination, lengthy analysis times, and large required analysis volumes. In addition, relatively few techniques currently exist for the convenient determination of headspace moisture in packaging systems. Efforts herein focused on the development and application of a new method for the rapid and simultaneous determination of headspace oxygen and moisture in pharmaceutical packages using micro-gas chromatography (GC). Studies showed that both headspace oxygen and moisture could be simultaneously quantified in <90 s on sample volumes of 50-100 L by employing GC with dual chromatographic analysis modules. Sampling issues common to manual syringe-based injections were also alleviated in the current studies by use of the built-in diaphragm pump sampling interface of the portable GC system. The performance of the analytical approach was evaluated and shown to exhibit excell

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Author

Hui Xu; Allen C. Templeton; Marta Zwierzynski; Rajiv Mahajan; Robert A. Reed

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)