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Bacterial Species-identifiable Magnetic Nanosystems for Early Sepsis Diagnosis and Extracorporeal Photodynamic Blood Disinfection by Jianhao Wang; Hao Wu; Yanmei Yang; Rong Yan; Yuan Zhao; Yanhao Wang; Aihong Chen; Shilong Shao; Pengju Jiang; Yong-Qiang Li is a Materials Science article available to read on EtoBox.
What is Bacterial Species-identifiable Magnetic Nanosystems for Early Sepsis Diagnosis and Extracorporeal Photodynamic Blood Disinfection about?
Despite the numerous bacteria detection and elimination techniques available nowadays, sensitive diagnosis and treatment of sepsis (caused by the presence of bacteria in the bloodstream), especially at the early stage, remain big challenges. Here we report a nanosystem for early sepsis diagnosis and complete extracorporeal blood disinfection, based on iron oxide magnetic nanoparticles functionalized with chlorin e6 molecules and bacterial species-identifiable aptamers (FeO-Ce6-Apt). We demonstrate that the FeO-Ce6-Apt nanosystem can achieve simultaneous blood bacterial species identification and enrichment in a single step, and the enriched bacteria can be easily detected with the assistance of fluorescence microscopic determination. Based on this FeO-Ce6-Apt nanosystem, successful diagnosis of sepsis caused by a single (Staphylococcus aureus) or multiple species (Staphylococcus aureus and Escherichia coli) of bacteria in mice has been realized. Compared to the gold standard blood culture method, this FeO-Ce6-Apt nanosystem-based strategy has a comparable detection sensitivity (around 10 colony-forming units) but a significantly shortened diagnosis turnaround time (within 1.5 h), r
Who reads Bacterial Species-identifiable Magnetic Nanosystems for Early Sepsis Diagnosis and Extracorporeal Photodynamic Blood Disinfection?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Jianhao Wang; Hao Wu; Yanmei Yang; Rong Yan; Yuan Zhao; Yanhao Wang; Aihong Chen; Shilong Shao; Pengju Jiang; Yong-Qiang Li
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Language
- EN
- Field
- Materials Science (Physical Sciences)