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Cortical Disinhibition Drives Freezing of Gait in Parkinson's Disease and an Exploratory Repetitive Transcranial Magnetic Stimulation Study by Huimin Sun; Caiting Gan; Lina Wang; Min Ji; Xingyue Cao; Yongsheng Yuan; Heng Zhang; Aidi Shan; Mengxi Gao; Kezhong Zhang is a Medicine article available to read on EtoBox.
What is Cortical Disinhibition Drives Freezing of Gait in Parkinson's Disease and an Exploratory Repetitive Transcranial Magnetic Stimulation Study about?
## Abstract ## Background Dysfunction of the primary motor cortex, participating in regulation of posture and gait, is implicated in freezing of gait (FOG) in Parkinson's disease (PD). ## Objective The aim was to reveal the mechanisms of “OFF‐period” FOG (OFF‐FOG) and “levodopa‐unresponsive” FOG (ONOFF‐FOG) in PD. ## Methods We measured the transcranial magnetic stimulation (TMS) indicators and gait parameters in 21 healthy controls (HCs), 15 PD patients with ONOFF‐FOG, 15 PD patients with OFF‐FOG, and 15 PD patients without FOG (Non‐FOG) in “ON” and “OFF” medication conditions. Difference of TMS indicators in the four groups and two conditions and its correlations with gait parameters were explored. Additionally, we explored the effect of 10 Hz repetitive TMS on gait and TMS indicators in ONOFF‐FOG patients. ## Results In “OFF” condition, short interval intracortical inhibition (SICI) exhibited remarkable attenuation in FOG patients (both ONOFF‐FOG and OFF‐FOG) compared to Non‐FOG patients and HCs. The weakening of SICI correlated with impaired gait characteristics in FOG. However, in “ON” condition, SICI in ONOFF‐FOG patients reduced compared to OFF‐FOG patients. Pharmacological
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- Author
- Huimin Sun; Caiting Gan; Lina Wang; Min Ji; Xingyue Cao; Yongsheng Yuan; Heng Zhang; Aidi Shan; Mengxi Gao; Kezhong Zhang
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)