Opening book details…
Can I read CD36 deficiency attenuates experimental mycobacterial infection on EtoBox?
CD36 deficiency attenuates experimental mycobacterial infection by Michael Hawkes; Xiaoming Li; Maryanne Crockett; Angelina Diassiti; Constance Finney; Gundula Min-Oo; W Conrad Liles; Jun Liu; Kevin C Kain is a Medicine article available to read on EtoBox.
What is CD36 deficiency attenuates experimental mycobacterial infection about?
## Abstract ## Background Members of the CD36 scavenger receptor family have been implicated as sensors of microbial products that mediate phagocytosis and inflammation in response to a broad range of pathogens. We investigated the role of CD36 in host response to mycobacterial infection. ## Methods Experimental __Mycobacterium bovis__ Bacillus Calmette-Guérin (BCG) infection in __Cd36__ ^__+/+__^ and __Cd36__ ^__-/-__^ mice, and __in vitro__ co-cultivation of __M. tuberculosis__, BCG and __M. marinum__ with __Cd36__ ^__+/+__^ and __Cd36__ ^__-/-__^murine macrophages. ## Results Using an __in vivo__ model of BCG infection in __Cd36__ ^__+/+__^ and __Cd36__ ^__-/-__^ mice, we found that mycobacterial burden in liver and spleen is reduced (83% lower peak splenic colony forming units, p < 0.001), as well as the density of granulomas, and circulating tumor necrosis factor (TNF) levels in __Cd36__ ^__-/-__^ animals. Intracellular growth of all three mycobacterial species was reduced in __Cd36__ ^__-/-__^ relative to wild type __Cd36__ ^__+/+__^ macrophages __in vitro__. This difference was not attributable to alterations in mycobacterial uptake, macrophage viability, rate of macrophage
Who reads CD36 deficiency attenuates experimental mycobacterial infection?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Michael Hawkes; Xiaoming Li; Maryanne Crockett; Angelina Diassiti; Constance Finney; Gundula Min-Oo; W Conrad Liles; Jun Liu; Kevin C Kain
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)