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Further Studies On The Properties Of Pure Vaccine Virus Cultivated In Vivo by Hideyo Noguchi is a Immunology and Microbiology article available to read on EtoBox.

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1. The virulence of vaccine virus for the testicular tissues increases until its maximum is finally reached. The selective increase is not associated with any loss, reduction, or modification in its virulence for the skin. A highly potent testicular vaccine is also highly active for the skin. 2. The testicular strain of vaccine virus has no more tendency to localize in various organs than the ordinary skin strain. Both may localize in adjacent lymph nodes when introduced intravenously, subcutaneously, or intratesticularly in sufficiently large quantities, but other organs are not involved. 3. Intravenous inoculation of an excessive amount of a powerful vaccine virus (1 to 2 cc. of undiluted stock emulsion), irrespective of whether it is from the testis or the skin, will result in a generalized eruption over the entire body surface of rabbits. The eruption may be confluent on mucous membranes of the mouth, nostrils, genitalia, etc. Intratesticular or subcutaneous inoculations of the same virus fail to produce this effect. 4. Subcutaneous or intravenous introduction of much smaller quantities of the virus does not cause an appreciable local or general reaction in the rabbit. But the

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Author

Hideyo Noguchi

Publisher

The Rockefeller University Press

Published

1918

Language

EN

Field

Immunology and Microbiology (Life Sciences)