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A Convenient Synthesis of Tetrasubstituted Pyrazoles from Nitrile Imines and 2-(Thioxothiazolidin-5-ylidene)acetates by Issa Yavari; Zohreh Taheri; Maryam Naeimabadi; Samira Bahemmat; Mohammad Halvagar is a Chemistry article available to read on EtoBox.
What is A Convenient Synthesis of Tetrasubstituted Pyrazoles from Nitrile Imines and 2-(Thioxothiazolidin-5-ylidene)acetates about?
Alkyl 2-(3-alkyl-4-oxo-2-thioxothiazolidin-5-ylidene)acetates react with hydrazonoyl chlorides in the presence of triethylamine to afford tetrasubstituted pyrazole derivatives. Formally, this transformation is regarded as a 1,3-dipolar cycloaddition of the exocyclic carbon–carbon double bond of the thioxothiazolidine derivatives with nitrile imines generated in situ. This efficient method provides fast access to a range of structurally diverse pyrazoles. The structure of a typical product is confirmed by X-ray crystallography.
Who reads A Convenient Synthesis of Tetrasubstituted Pyrazoles from Nitrile Imines and 2-(Thioxothiazolidin-5-ylidene)acetates?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Issa Yavari; Zohreh Taheri; Maryam Naeimabadi; Samira Bahemmat; Mohammad Halvagar
- Publisher
- Georg Thieme Verlag KG
- Published
- 2018
- Language
- EN
- Field
- Chemistry (Physical Sciences)