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Can I read Targeted regulated cell death with small molecule compounds in colorectal cancer: Current perspectives of targeted therapy and molecular mechanisms on EtoBox?
Targeted regulated cell death with small molecule compounds in colorectal cancer: Current perspectives of targeted therapy and molecular mechanisms by Ru Li; Yongya Wu; Yan Li; Wen Shuai; Aoxue Wang; Yumeng Zhu; Xiuying Hu; Yong Xia; Liang Ouyang; Guan Wang is a Chemistry article available to read on EtoBox.
What is Targeted regulated cell death with small molecule compounds in colorectal cancer: Current perspectives of targeted therapy and molecular mechanisms about?
Colorectal cancer (CRC), a tumor of the digestive system, is characterized by high malignancy and poor prognosis. Currently, targeted therapy of CRC is far away from satisfying. The molecular mechanisms of regulated cell death (RCD) have been clearly elucidated, which can be intervened by drug or genetic modification. Numerous studies have provided substantial evidence linking these mechanisms to the progression and treatment of CRC. The RCD includes apoptosis, autophagy-dependent cell death (ADCD), ferroptosis, necroptosis, and pyroptosis, and immunogenic cell death, etc, which provide potential targets for anti-cancer treatment. For the last several years, small-molecule compounds targeting RCD have been a well concerned therapeutic strategy for CRC. This present review aims to describe the function of small-molecule compounds in the targeted therapy of CRC via targeting apoptosis, ADCD, ferroptosis, necroptosis, immunogenic dell death and pyroptosis, and their mechanisms. In addition, we prospect the application of newly discovered cuproptosis and disulfidptosis in CRC. Our review may provide references for the targeted therapy of CRC using small-molecule compounds targeting RCD
Who reads Targeted regulated cell death with small molecule compounds in colorectal cancer: Current perspectives of targeted therapy and molecular mechanisms?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Ru Li; Yongya Wu; Yan Li; Wen Shuai; Aoxue Wang; Yumeng Zhu; Xiuying Hu; Yong Xia; Liang Ouyang; Guan Wang
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Chemistry (Physical Sciences)