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What is Nitric Oxide Regulates CREB in Neurons about?
This study investigates the role of nitric oxide (NO) in controlling CREB-mediated gene expression in neurons, challenging the prevailing view that CREB is constitutively bound to target genes. The authors demonstrate that BDNF induces rapid CREB binding to DNA, which is regulated by an NO-dependent signaling pathway, independent of CREB phosphorylation at Ser133. This research highlights the distinct mechanisms by which extracellular stimuli influence CREB activity and gene expression in neuronal contexts.
- Author
- manuelsaponaro.moto
- Language
- EN