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This document discusses the thermodynamics of general anesthesia, proposing an extension of the Meyer-Overton rule that incorporates free energy changes and melting point depression in lipid membranes. The authors explain how this model accounts for the pressure reversal of anesthesia and the effects of inflammation and divalent cations on anesthetic efficacy. The study emphasizes the relationship between anesthetic solubility in lipid membranes and their action, suggesting a thermodynamic perspective on th

Author

musicsaif123

Language

EN