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A Covalent Chemical Probe For Protease With Antialphaviral: Chikungunya by Prasun Pradhan is a document available to read on EtoBox.

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The document discusses the identification of a potent covalent inhibitor, vinyl sulfone SGC-NSP2PRO-1, for the Chikungunya nsP2 cysteine protease, which demonstrates significant antiviral activity and selectivity against other cysteine proteases. This compound effectively reduces viral titers of Chikungunya and other alphaviruses, showing promise as a chemical probe for studying viral replication and virulence. The study emphasizes the need for effective therapeutic interventions for alphavirus infections,

Author

Prasun Pradhan

Language

EN