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Structure of the E2 DNA-Binding Domain from Human Papillomavirus Serotype 31 at 2.4 Å by Dirksen E. Bussiere; Xiangpeng Kong; David A. Egan; Karl Walter; Thomas F. Holzman; Frank Lindh; Terry Robins; Vincent L. Giranda is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Structure of the E2 DNA-Binding Domain from Human Papillomavirus Serotype 31 at 2.4 Å about?

The papillomaviruses are a family of small doublestranded DNA viruses which exclusively infect epithelial cells and stimulate the proliferation of those cells. A key protein within the papillomavirus life-cycle is known as the E2 (Early 2) protein and is responsible for regulating viral transcription from all viral promoters as well as for replication of the papillomavirus genome in tandem with another protein known as E1. The E2 protein itself consists of three functional domains: an N-terminal trans-activation domain, a proline-rich linker, and a Cterminal DNA-binding domain. The ®rst crystal structure of the human papillomavirus, serotype 31 (HPV-31), E2 DNA-binding domain has been determined at 2.4 A Ê resolution. The HPV DNA-binding domain monomer consists of two ±± repeats of approximately equal length and is arranged as to have an antiparallel -sheet ̄anked by the two -helices. The monomers form the functional in vivo dimer by association of the -sheets of each monomer so as to form an eight-stranded anti-parallel -barrel at the center of the dimer, with the -helices lining the outside of the barrel. The overall structure of HVP-31 E2 DNAbinding domain is similar to both th

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Author

Dirksen E. Bussiere; Xiangpeng Kong; David A. Egan; Karl Walter; Thomas F. Holzman; Frank Lindh; Terry Robins; Vincent L. Giranda

Publisher

International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr) (ISSN 0907-4449)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)