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Can I read STAT3 and Its Targeting Inhibitors in Oral Squamous Cell Carcinoma on EtoBox?
STAT3 and Its Targeting Inhibitors in Oral Squamous Cell Carcinoma by Mingjing Jiang; Bo Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is STAT3 and Its Targeting Inhibitors in Oral Squamous Cell Carcinoma about?
Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of oral mucosa and accounts for approximately 90% of oral cancers. Current therapeutic approaches do not yet meet the needs of patients, and the 5-year survival rate of patients with OSCC is only 50%. Recent studies have revealed that the signal transducer and activator of transcription 3 (STAT3) plays a key role in the development and progression of OSCC. STAT3 is overexpressed and constitutively activated in OSCC cells, and promotes cancer cell proliferation and anti-apoptosis, migration and invasion, angiogenesis, radiotherapy resistance, and immune escape, as well as stem cell self-renewal and differentiation by regulating the transcription of its downstream target genes. Inhibitors of the STAT3 signaling pathway have shown the promising anticancer effects in vitro and in vivo, and STAT3 is expected to be a molecular target for the treatment of OSCC. In this review, we highlight the oncogenic significance of STAT3 in OSCC with an emphasis on the therapeutic approaches and effective small molecule inhibitors targeting STAT3. Finally, we also propose the potential research directions in the expec
Who reads STAT3 and Its Targeting Inhibitors in Oral Squamous Cell Carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mingjing Jiang; Bo Li
- Publisher
- MDPI AG
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)