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Can I read Placenta Growth Factor is Induced in Human Keratinocytes during Wound Healing on EtoBox?
Placenta Growth Factor is Induced in Human Keratinocytes during Wound Healing by Cristina M. Failla; Teresa Odorisio; Francesca Cianfarani; Cataldo Schietroma; Giovanna Zambruno; Pietro Puddu is a Medicine article available to read on EtoBox.
What is Placenta Growth Factor is Induced in Human Keratinocytes during Wound Healing about?
Placenta growth factor (PlGF) is a dimeric glycoprotein, structurally and functionally related to the vascular endothelial growth factor, a potent angiogenic/permeability factor known to play a role in the neoangiogenesis during wound repair. In this study we evaluated the expression of PlGF in human keratinocytes and investigated its possible role in wound healing. Northern blot analysis on cultured keratinocytes revealed a 1.7 kb mRNA transcript and reverse transcriptase-polymerase chain reaction allowed the detection of two PlGF isoforms generated by alternative RNA splicing. PlGF and vascular endothelial growth factor homodimers as well as vascular endothelial growth factor/PlGF heterodimers could be detected in keratinocyte conditioned medium. Increased expression of both PlGF mRNA and protein was observed upon treatment of keratinocytes with epidermal growth factor, transforming growth factor-alpha, transforming growth factor-beta, and interleukin-6, all cytokines present at the wound site during the early phase of repair. The analysis of human full-thickness healing wounds revealed appreciable levels of PlGF mRNA and protein in the migrating keratinocytes starting from day 3
Who reads Placenta Growth Factor is Induced in Human Keratinocytes during Wound Healing?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Cristina M. Failla; Teresa Odorisio; Francesca Cianfarani; Cataldo Schietroma; Giovanna Zambruno; Pietro Puddu
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; Springer Science and Business Media LLC; Wiley (ISSN 0022-202X)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)