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The Effect of Disease-modifying Anti-rheumatic Drugs on Skeletal Muscle Mass in Rheumatoid Arthritis Patients: a Systematic Review with Meta-analysis by Thales R. Hein; Leonardo Peterson; Barbara J. Bartikoski; Juliana Portes; Rafaela C. Espírito Santo; Ricardo M. Xavier is a Medicine article available to read on EtoBox.
What is The Effect of Disease-modifying Anti-rheumatic Drugs on Skeletal Muscle Mass in Rheumatoid Arthritis Patients: a Systematic Review with Meta-analysis about?
## Abstract ## Introduction Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic and systemic inflammation. Besides, it is known that RA patients may present several comorbidities, such as sarcopenia, a condition where patients present both muscle mass and muscle quality impairment. RA treatment is mostly pharmacological and consists in controlling systemic inflammation and disease activity. Despite that, the effect of pharmacological treatment on sarcopenia is not well characterized. ## Objective To summarize the effects of disease-modifying anti-rheumatic drugs (DMARDs) on skeletal muscle tissue in rheumatoid arthritis (RA) patients. ## Methods A systematic review of randomized clinical trials and observational studies was conducted using MEDLINE, Embase, Cochrane Library, and Web of Science. We selected studies with rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs (DMARDs) that analyzed muscle mass parameters such as lean mass and appendicular lean mass. Methodological quality was assessed using the Newcastle-Ottawa Quality Assessment Scale. Standardized mean difference (SMD) and 95% confidence intervals (CI) were set. A m
Who reads The Effect of Disease-modifying Anti-rheumatic Drugs on Skeletal Muscle Mass in Rheumatoid Arthritis Patients: a Systematic Review with Meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Thales R. Hein; Leonardo Peterson; Barbara J. Bartikoski; Juliana Portes; Rafaela C. Espírito Santo; Ricardo M. Xavier
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)